APPLICATION OF CURCUMINOIDS-LOADED NANOEMULSION FOR CANCER THERAPY

INTRODUCTION: Curcuminoids and Oleic acid, reported in the literature as antioxidant antitumor agents, were combined nanoemulsion, using Pluronic F127 a stabilizer.
 METHODS: The main objective is to investigate its cytotoxic activity against cancer cells.
 RESULTS AND DISCUSSION: nanoemulsion show values of particle size (251.4 ± 4.6 nm), zeta potential (-34.8 1.0 mV), pH (4.8) classifying it stable non-irritating for pharmacological applications. results indicate that, toxicity test fish (Zebrafish), nanoformulation proved be biosafe evaluation action (by DPPH) showed excellent activity. Furthermore, vitro cytotoxicity studies, nanoemulsions good activity, ideal fighting Colorectal, Glioblastoma, Leukemia cancers more effectively Prostate cancer.